The Indian Knowledge System (IKS), an ancient Indian wisdom, is now included in syllabus as part of NEP 2020. The researchers attempted to compare the academic performance of Commerce and Information Technology students towards IKS topics of Vedic Mathematics and Ayurveda, but no significant differences were found between their academic performance. Furthermore, Overall IKS was reported to be more beneficial in comparison to conventional subjects in the viewpoint of students except for ease of understanding and better career opportunities. There were substantial differences reported in how IKS is perceived in comparison to conventional subjects by offering valuable insights into health and wellness. The researchers recommend developing a balanced curriculum, making IKS more application oriented towards industries, and using innovative teaching methods so that students remain interested despite IKS’s perceived difficulty.