This study assessed the effectiveness of the Kilos Unlad (KU) Framework as a social case management strategy for improving the multi-dimensional well-being of Pantawid Pamilyang Pilipino Program (4Ps) beneficiaries in Lumbayanague, Lanao del Sur. Using a mixed-methods research design, quantitative data were collected from 242 beneficiaries to examine their level of engagement with the KU Framework and its perceived effects on economic, social, psychological, and health well-being. Qualitative data were gathered through interviews with case managers and service providers to explore implementation challenges and mechanisms for improvement. Findings revealed generally high engagement among beneficiaries, particularly in KU activities, although understanding of specific KU tasks indicated a need for improved orientation. The KU Framework was perceived as effective in enhancing financial literacy, family relationships, community participation, confidence, motivation, emotional resilience, and preventive health behaviors. However, income stability remained a persistent challenge, highlighting structural and resource-related constraints. Qualitative insights supported these results, emphasizing improvements in self-sufficiency, social cohesion, stress management, and health awareness, while also identifying resource limitations, logistical issues, and the need for stronger policy and institutional support.